General Information

  • ID:  hor006695
  • Uniprot ID:  Q9IAU2
  • Protein name:  Trp-8 progonadoliberin
  • Gene name:  NA
  • Organism:  Rana dybowskii (Dybovsky's frog) (Korean brown frog)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  Expressed in forebrain but not in testis, ovary, kidney and liver.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rana (subgenus), Rana (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QHWSYGLWPGGKREVEGLQESYSEVPNEVSFTDPQHFERSIPQNRISLVREALMNWLEGENTRKKI
  • Length:  66(25-90)
  • Propeptide:  MSRHVTVVLLLAVVLLLSSHMSHGQHWSYGLWPGGKREVEGLQESYSEVPNEVSFTDPQHFERSIPQNRISLVREALMNWLEGENTRKKI
  • Signal peptide:  MSRHVTVVLLLAVVLLLSSHMSHG
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9IAU2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006695_AF2.pdbhor006695_ESM.pdb

Physical Information

Mass: 894518 Formula: C346H527N99O105S
Absent amino acids: C Common amino acids: E
pI: 5.67 Basic residues: 10
Polar residues: 19 Hydrophobic residues: 18
Hydrophobicity: -98.33 Boman Index: -16779
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 66.36
Instability Index: 4091.82 Extinction Coefficient cystines: 19480
Absorbance 280nm: 299.69

Literature

  • PubMed ID:  11026571
  • Title:  Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone ([Trp8] GnRH) in frog brain.